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SCIENTIFIC RESEARCHES ABOUT HEART HEALTH CARE DIETARY SUPPLEMENT There are many worldwide researches defining the high power of the organic components for human heart care supplements manufacturing industry. Scientific pubblications from University in Japan, USA, Italy, Australia,... confirms the quality and efficience of the Organic Lycopene to avoid main human diseases as Parkinson, Alzheimer disease, cancer and others. The scientific staff of Pierre Italy has used all of them as scientific reference to improve, to define our organic dietary supplements... APPLY FOR DISTRIBUTION

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ENZYME-AIDED EXTRACTION OF LYCOPENE FROM HIGH PIGMENT TOMATO CULTIVARS BY SUPERCRITICAL CARBON DIOXIDE, 2014

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Lenucci, De Caroli, Marrese, Andrea Iurlaro, Leonardo Rescio, Volker Böhm, Dalessandro, Gabriella Piro by Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali (Di.S.Te.B.A.), Università del Salento, Italy, PIERRE s.r.l., 73013 Galatina (LE), Italy, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 25-29, 07743 Jena, Germany
THIS WORK REPORTS A NOVEL ENZYME-ASSISTED PROCESS for lycopene concentration into a freeze-dried tomato matrix and describes the results of laboratory scale lycopene supercritical CO2 (SC-CO2) extractions carried out with untreated (control) and enzyme-digested matrices. The combined use of food-grade commercial plant cell-wall glycosidases (Celluclast/Novozyme plus Viscozyme) allows to increase lycopene (153%) and lipid (137%) concentration in the matrix and rises substrate load onto the extraction vessel (46%) compared to the control. The addition of an oleaginous co-matrix (hazelnut seeds) to the tomato matrix (1:1 by weight) increases CO2 diffusion through the highly dense enzyme-treated matrix bed and provides lipids that are co-extracted increasing lycopene yield. Under the same operative conditions (50 MPa, 86 C, 4 mL min1 SC-CO2 flow) extraction yield from control and Celluclast/Novozyme + Viscozyme- treated tomato matrix/co-matrix mixtures was similar, exceeding 75% after 4.5 h of extraction. However, the total extracted lycopene was 3 times higher in enzyme-treated matrix than control. 2014 Published by Elsevier Ltd.

Italian dietary and health food supplements businessProduzione Italiana di integratori alimentari biologici

CERTIFIED WORLD SCIENTIFIC RESEARCHES - ORGANIC LYCOPENE SUPPLEMENTS MANUFACTURING

Fabrica de integrador o suplemento alimenticio

1

Rissanen T, Voutilainen S, Nyyssonen K, Salonen JT. - Research Institute of Public Health, University of Kuopio, Kuopio, Finland 70211. Lycopene, atherosclerosis, and coronary heart disease. Exp Biol Med (Maywood) 2002 Nov; 227(10):900-7 [File : 1ExpBiolMed2002.pdf]

 

2

Rao AV. - Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2. Lycopene, tomatoes, and the prevention of coronary heart disease. Exp Biol Med (Maywood) 2002 Nov; 227(10):908-13 [File : 2ExpBiolMed2002.pdf]

 

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Das S, Otani H, Maulik N, Das DK. Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA. Lycopene, tomatoes, and coronary heart disease. Free Radic Res. 2005 Apr;39(4):449-55

 

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Edmond Kato Kabagambe, Jeremy Furtado, Ana Baylin, and Hannia Campos - Some Dietary and Adipose Tissue Carotenoids Are Associated with the Risk of Nonfatal Acute Myocardial Infarction in Costa Rica1,2 - J. Nutr. 135: 1763–1769, 2005. [File =142 JN 2005.pdf]

 

6

Kohlmeier L, Kark JD, Gomez-Gracia E, Martin BC, Steck SE, Kardinaal AF, Ringstad J, Thamm M, Masaev V, Riemersma R, Martin-Moreno JM, Huttunen JK, Kok FJ - Lycopene and myocardial infarction risk in the EURAMIC Study. Am J Epidemiol 1997 Oct 15;146(8):618-626 [File : 6AmJEpid1997.pdf]

 

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9

Arab L, Steck S - School of Public Health, University of North Carolina, Chapel Hill. Lycopene and cardiovascular disease. Am J Clin Nutr 2000 Jun;71(6 Suppl):1691S-5S; discussion 1696S-7SV [File : 9AmJClinNutr2000.pdf]

 

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Rao AV, Agarwal S – Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada. Role of antioxidant lycopene in cancer and heart disease J Am Coll Nutr 2000 Oct;19(5):563-9 Review [ File : 10JAmCollNutr2000.pdf]

 

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Hsueh YM, Wu WL, Huang YL, Chiou HY, Tseng CH, Chen CJ - Department of Public Health, School of Medicine, Taipei Medical College, Taiwan, ROC. Low serum carotene level and increased risk of ischemic heart disease related to long-term arsenic exposure. Atherosclerosis 1998 Dec;141(2):249-57

 

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Agarwal S, Rao AV - Department of Nutritional Sciences, University of Toronto, ON, Canada Carotenoids and chronic diseases. Drug Metabol Drug Interact 2000;17(1-4):189-210

 

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Fuhrman B, Elis A, Aviram M - Lipid Research Laboratory, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel. Hypocholesterolemic effect of lycopene and betacarotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. Biochem Biophys Res Commun 1997 Apr 28;233(3):658-662 . [File : 15BBRC1997.pdf]

 

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Agarwal S, Rao AV - Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ont. Tomato lycopene and its role in human health and chronic diseases. CMAJ 2000 Sep 19;163(6):739-44 [File : 16CMAJ2000.pdf]

 

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Rissanen T, Voutilainen S, Nyyssonen K, Salonen R, Salonen JT - Research Institute of Public Health, University of Kuopio, Finland, and Inner Savo Health Centre (J.T.S.), Finland. Low plasma lycopene concentration is associated with increased intima-media thickness of the carotid artery wall. Arterioscler Thromb Vasc Biol 2000 Dec;20(12):2677-81 [File : 21ArtThrVascBiol2000.pdf]

 

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Paul Knekt; John Ritz; Mark A. Pereira; Eilis J O’Reilly; Katarina Augustsson; Gary E. Fraser; Uri Goldbourt; Berit L. Heitmann; Goran hallmans ; Simin Liu ; Pirjo Pietinen ; Donna Spiegelmam ; June Stevens ; Jarmo Vitarmo; Walter C. Willet; Eric B. Rimm; Alberto Ascherio; Antioxidant Vitamins and Coronary Heart Disease risk : a pooled analysis of 9 Cohorts. Am J. Clin Nutr. 2004; 80 : 1508-20 [File : 22AJCN2004.pdf]

 

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Aviram M, Fuhrman B - Lipid Research Laboratory, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel. LDL oxidation by arterial wall macrophages depends on the oxidative status in the lipoprotein and in the cells: role of prooxidants vs. antioxidants. Mol Cell Biochem 1998 Nov;188(1-2):149-59

 

21

Tertov VV, Sobenin IA, Kaplun VV, Orekhov AN - Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia - Antioxidant content in low density lipoprotein and lipoprotein oxidation in vivo and in vitro. Free Radic Res 1998 Aug;29(2):165-73

 

22

Plat J, van Onselen EN, van Heugten MM, Mensink RP - Department of Human Biology, Maastricht University, Maastricht, The Netherlands. Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters. Eur J Clin Nutr 2000 Sep;54(9):671-7

 

23

Hoffmann J, Linseisen J, Riedl J, Wolfram G - Institute of Nutritional Sciences, Technical University of Munich. Dietary fiber reduces the antioxidative effect of a carotenoid and alpha-tocopherol mixture on LDL oxidation ex vivo in humans. Eur J Nutr 1999 Dec;38(6):278-85

 

24

Cockey CD - Lycopene may contribute to heart health. AWHONN Lifelines 2002 Jun-Jul;6(3):206

 

25

Carroll YL, Corridan BM, Morrissey PA - Department of Food Science and Technology, University College Cork, Ireland. Lipoprotein carotenoid profiles and the susceptibility of low density lipoprotein to oxidative modification in healthy elderly volunteers. Eur J Clin Nutr 2000 Jun;54(6):500-7

 

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Giugliano D - Dipartimento di Gerontologia, Geriatria e Malattie del Metabolismo, Seconda Universita di Napoli, Italy. Dietary antioxidants for cardiovascular prevention. Nutr Metab Cardiovasc Dis 2000 Feb;10(1):38-44

 

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Martin KR, Wu D, Meydani M - Vascular Biology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, 02111, Boston, MA, USA. The effect of carotenoids on the expression of cell surface adhesion molecules and binding of monocytes to human aortic endothelial cells. Atherosclerosis 2000 Jun;150(2):265-74

 

28

Upritchard JE, Sutherland WH, Mann JI - Department of Human Nutrition, University of Otago, Dunedin, New Zealand. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000 Jun;23(6):733-8

 

29

Linseisen J, Hoffmann J, Riedl J, Wolfram G - Institute of Nutrition Science of the Technical University of Munich, Freising-Weihenstephan, Freising-Weihenstephan, D-85350, Germany - Effect of a Single Oral Dose of Antioxidant Mixture (Vitamin E, Carotenoids) on the Formation of Cholesterol Oxidation Products after ex vivo LDL Oxidation in Humans. Eur J Med Res 1998 Feb 21;3(1/2):5-12

 

30

Fuhrman B, Volkova N, Rosenblat M, Aviram M - Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel. Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antioxid Redox Signal 2000 Fall;2(3):491-506

 

31

Clinton, S. K.; Craft, N. E.; Degroff, V. L.; Hadley, C.W.; Harris, G. K.; Miller, B. C.; Schwartz, S. J The consumption of processed tomato products enhances plasma lycopene concentrations and reduces oxidative damage to lipoproteins in humans. FASEB Journal VOL. 15 NO. 4 March 7, 2001 PP. A297. March 31- April 04, 2001 Annual Meeting of the Federation of American Societies for Experimental Biology on Experimental Biology 2001

 

32

Rissanen TH, Voutilainen S, Nyyssonen K, Lakka TA, Sivenius J, Salonen R, Kaplan GA, Salonen JT. Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland. Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr 2001 Jun;85(6):749-54

 

33

Paran, Esther; Engelhard, Yehiel - Hypertension Unit, Soroka University medical Center, Beer Sheva, Israel Effect of tomato's lycopene on blood pressure, serum lipoproteins, plasma homocysteine and oxidative stress markers in grade I hypertensive patients. American Journal of Hypertension Vol. 14 N. 4 Part 2- April, 2001 PP. 141A. May 15-19, 2001 [Abstract : 49AJH2001.pdf]

 

34

Tonomoto, Mariko; Maruyama, Chizuko; Imamura, Kayoko; Harada, Miho; Egami, Satoko; Baba, Naoko; Ayaori, Makoto; Inakuma, Takahiro; Ishikawa, Toshitsugu; Oshima, Shunji; Suzukawa, Michio - Department of Food and Nutrition, Japan Women's University, Bunkyo-ku, Tokyo, 112-8681, Japan - Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification. Journal of Nutritional Science and Vitaminology VOL.47 N.3 June, 2001 PP. 213-221

 

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McQuillan BM, Hung J, Beilby JP, Nidorf M, Thompson PL. Gairdner Campus of the Heart Research Institute of Western Australia, Western, Nedlands, Perth, Australia Antioxidant vitamins and the risk of carotid atherosclerosis. The perth carotid ultrasound disease assessment study (CUDAS). J Am Coll Cardiol 2001 Dec;38(7):1788-1794 - [File : 57 JACC 2001.pdf]

 

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Gianetti J, Pedrinelli R, Petrucci R, Lazzerini G, De Caterina M, Bellomo G, De Caterina R. C. N. R. Institute of Clinical Physiology, University of Pisa, Pisa, Italy. Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis. Am Heart J 2002 Mar;143(3):467-74 [File : 58AmHeartJ2002.pdf]

 

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Ruiz Rejon F, Martin-Pena G, Granado F, Ruiz-Galiana J, Blanco I, Olmedilla B. - Servicio de Cardiologia, Servicio de Medicina Interna, Hospital de Mostoles, Madrid, Spain. Plasma status of retinol, alpha- and gammatocopherols, and main carotenoids to first myocardial infarction: case control and follow-up study. Nutrition 2002 Jan;18(1):26-31

 

39

Tero Hirvoven; Jarmo Virtamo ; Pasi Korhonen ; Demetrius Albanes ; Pirjo Pietinen. Intake of Flavonoids , carotenoids ,Vitamin C, Vitamin E and Risk of Stroke in Male Smokers. Journal of the American Heart Association. Stroke 2000; 31 ; 2301-2306 . [File : 68Stroke2000.pdf]

 

40

A.Elisabeth Hak; Jing Ma; Calpurnya B.Powell; Hannia Campos; J.Michael Gaziano; Walter C.Willet;Meier Stampfer. Prospective Study of Plasma Carotenoids and Tocopherols in relation to risk of Ischemic Stroke. Journal of the American Heart Association. Stroke 2004; 35 ; 1584-1588 . [File : 69Stroke2004.pdf]

 

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Bansal P, Gupta SK, Ojha SK, Nandave M, Mittal R, Kumari S, Arya DS. - Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. Cardioprotective effect of lycopene in the experimental model of myocardial ischemia-reperfusion injury. Mol Cell Biochem. 2006 Apr 7

 

43

Engelhard YN, Gazer B, Paran E. - Hypertension Unit, Faculty of Health Sciences, Soroka University Medical Centre, Ben Gurion, University of the Negev, 84101 Beer Sheva, Israel. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: double-blind, placebo-controlled pilot study. Am Heart J. 2006 Jan;151(1):100. [File : 72AmHeartJ2006.pdf]

 

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Kaliora AC, Dedoussis GV, Schmidt H. - Department of Science of Dietetics-Nutrition, Harokopio University of Athens, Greece. Dietary antioxidants in preventing atherogenesis. Atherosclerosis. 2005 Nov 25

 

45

Karimi G, Ramezani M, Abdi A. Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Protective effects of lycopene and tomato extract against doxorubicin-induced cardiotoxicity. Phytother Res. 2005 Oct;19(10):912-4. Copyright (c) 2005 John Wiley & Sons, Ltd.

 

46

Hsiao G, Wang Y, Tzu NH, Fong TH, Shen MY, Lin KH, Chou DS, Sheu JR. - Graduate Institute of Pharmacology, Taipei Medical University, Taipei, Taiwan. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med. 2005 Oct;146(4):216-26

 

47

Yilmaz S, Atessahin A, Sahna E, Karahan I, Ozer S. - Department of Biochemistry, College of Veterinary Medicine, Faculty of Veterinary, Firat (Euphrates) University, Turkey. Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity. Toxicology. 2006 Feb 1;218(2-3):164-71. Epub 2005 Dec 1

 

48

Sesso HD, Buring JE, Norkus EP, Gaziano JM. - Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men. Am J Clin Nutr. 2005 May;81(5):990-7. [Full text ; file : 77AmJClinNutr2005.pdf]

 

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Sesso HD. - Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School and Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, USA. Carotenoids and cardiovascular disease: what research gaps remain? Curr Opin Lipidol. 2006 Feb;17(1):11-16.

 

50

Sesso HD, Buring JE, Norkus EP, Gaziano JM. - Division of Preventive Medicine, Department of Medicine, Brigham and Women's , Hospital and Harvard Medical School, Boston, MA 02215, USA. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women. Am J Clin Nutr. 2004 Jan; 79(1): 47- 53. [File : 79 AJCN 2004.pdf

 

51

Rissanen TH, Voutilainen S, Nyyssonen K, Salonen R, Kaplan GA, Salonen JT. Research Institute of Public Health (THR, SV, KN, RS, and JTS) and the Department of Public Health and General Practice (THR and JTS), University of Kuopio, Kuopio, Finland. Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 2003 Jan;77(1):133-8 [File : 80AmJClinNutr2003.pdf]

 

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Hak AE, Stampfer MJ, Campos H, Sesso HD, Gaziano JM, Willett W, Ma J. - Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Ave, Boston, Mass 02115-5804, USA. Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians. Circulation. 2003 Aug 19;108(7):802-7. Epub 2003 Aug 04. [File : 83Circulation2003.pdf

 

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Ahuja KD, Pittaway JK, Ball MJ. - School of Human Life Sciences, University of Tasmania, Launceston, Tasmania, Australia. Effects of olive oil and tomato lycopene combination on serum lycopene, lipid profile, and lipid oxidation. Nutrition. 2006 Jan 12;

 

56

Chang CY, Chen JY, Ke D, Hu ML. Department of Neurology, Chi-Mei Foundation Hospital, Tainan, Taiwan, ROC. Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: correlation to inflammation markers and neurological deficits. Nutrition. 2005 Oct;21(10):987-93

 

57

M.A.Newaz; N.N.A. Nawal– Faculty of Medicine Kuala Lampur - Malysia – Effect of alfa–tocopherol on lipid peroxidation and total antioxidant status in spontaneously hyeprtensive rats. The American Journal of Hypertension . AJH 1998 ; 11:1480-1485. [File : 91AJH1998.pdf]

 

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59

Lee DH, Gross MD, Jacobs Jr DR. Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea. Association of Serum Carotenoids and Tocopherols with {gamma}- Glutamyltransferase: The Cardiovascular Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2004 Jan 15

 

60

Hadley CW, Clinton SK, Schwartz SJ. - The Department of Food Science and Technology, The James Cancer Hospital and Solove Research Institute, Columbus, OH 43210, USA. -The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage. J Nutr 2003 Mar;133(3):727-32 [File : 97 JNutr2003.pdf]

 

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Jonasson L, Wikby A, Olsson AG. - Department of Cardiology, Heart Center, University Hospital, S-581 85 Linkoping, Sweden. Low serum beta-carotene reflects immune activation in patients with coronary artery disease. Nutr Metab Cardiovasc Dis. 2003 Jun;13(3):120-5

 

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Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP. Centro Invecchiamento Cellulare, I.D.I. (IRCCS), Roma, Italy. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Biofactors. 2003; 18(1-4): 113-24.

 

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Kaumudi J Joshipura; Frank B. Hu; JoAnn E. Manson; Meier J. Stampfer ; Eric B. Rimm ; Frank E. Spelzen; Graham Colditz; Alberto Ascherio; Bernard Rosner ; Donna Spiegelmam ; Walter C. Willet. The effect of Fruits and Vegetable intake on Risk for Coronary Heart Disease. Ann. Intern. Med. 2001; 134: 1106-1114. [File : 108AIM2001.pdf

 

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H.D. Sesso, Simin Liu, J.Michael Graziano and J.E. Buring. Dietary Lycopene, Tomato based product and cardiovascular disease in women. The Journal of Nutrition. J. Nutr 133 : 2336-2341 , 2003 [file : 112JNutr2003.pdf]

 

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71

Paran Esther; Engelhard Yehiel, Inbal Hazan-Hallevy, Yoav Sharoni, Joseph Levy - Hypertension Unit, Soroka University medical Center, Beer Sheva, Israel - Effect of standardized tomato extract on blood pressure, endothelial function and plasma Lycopene level in treated hypertensive patients. American Journal of Hypertension Vol. 18 No. 5 Part 2- May 2005 [Abstract : 114AJH2005.pdf

 

72

Sudesh Vasdev ; Vicki Gill - Department of medicine and laboratory medicine, Health Sciences Centre, Memorial University of Newfoundland St.John’s , Newfoundland , Canada - Antioxidants in the treatment of Hypertension. International Journal of Angiology 14 :60-73 (2005) [ File : 115IJA2005.pdf

 

73

K. Asplund - Department of Medicine- University Hospital – Stockholm , Sweden. Pierre srl – Galatina, Italy–Dietary Supplement with Organic Lycopene (Patent n.WO/2008/015490). LICOMPLETE™ was developed by Pierre, working with University of Salento and CNR (National Research Centre) Antioxidant Vitamins in the prevention of cardiovascular disease. Review - Journal of Internal Medicine 251: 372-392 (2002) [File : 116JIM2002.pdf

 

74

J.H.Johnn ; S.Ziebland ; P Yudkin ; L.S.Roe; H.A.Neil – Oxford Fruit and Vegetable Study Group. Effect of fruit and vegetable on plasma antioxidant concentrations and blood pressure : a randomised controlled trial – Lancet 2002; 359 : 1969-74 [File : 117Lancet2002.pdf]

 

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Brendan M. Mc.Quillan; Joseph Hung ; John P. Beilby ; Mark Nidorf ; Peter L. Thompson. CLINICAL STUDIES. Antioxidant vitamins and the risk of carotenoid atherosclerosis : the perth carotid ultrasound disease assessment study (CUDAS) – J. Am. Coll. Cardiol. 2001 ; 38; 1788-1794 [File : 119 JACC2001.pdf]

 

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Alberto Ascherio ; Eric B. Rimm; Miguel A. Hernan; Edward Giovannucci ; Ichiro Kawachi; Meir J. Stompfer; Walter C. Willet. Relation of Consumption of Vitamin E, Vitamin C and Carotenoid to risk fort Stroke among the men in United States Am. Int. Med. 1999 ; 130; 963-970 [File:120AmIntMed 1999.pdf

 

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Stephen B. Kritchevsky. Department of Preventive Medicine , University of Tennesee. Memphis. B. Carotene, Carotenoids and the prevention of Coronary Heart Disease – J. Nutr. 1999; Vol 129 ; 5-8 [File : 121JNutr1999.pdf]

 

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Francene M. Steinberg and Alan Chait. Antioxidant vitamin supplementation and lipid peroxidation in smokers – Am J. Clin Nutr. 1998; Vol 68 ; 319-27 [File : 122AmJClinNutr1998.pdf

 

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Stephen B. Krichevinsky ; Andrew J. Bush ; Marco Pahor ; Myran D. Gross. Serum Carotenoids and Markers of Inflammation in Nonsmokers. American Journal of Epidemiology. AJE 2000 ; Vol. 152 N.11 ; 1065 –71 [File : 125AJE2000.pdf

 

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A.V. Rao and S.Agarwal. Department of Sciences ,University of Toronto, Ontario, Canada. Effect of diet and smoking on serum Lycopene and Lipid peroxidation. Nutritional Research , Vol 18, No 4 , p 713-721, 1998 [File : 126NR1998.pdf

 

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Tammy M. Bray, PhD - Dean and Professor College of Health and Human Sciences Oregon State University Corvallis- OR - Putative Anti-inflammatory Functions of Lycopene in Prevention of Cardiovascular Disease [File : 127 Bray Presentation.pdf]

 

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Milde J, Elstner EF, Grassmann J. Department of Plant Sciences, Institute of Phytopathology, Laboratory for Applied Biochemistry, Munich Technical University, Freising-Weihenstephan, Germany. Synergistic effects of phenolics and carotenoids on human low-density lipoprotein oxidation. Mol Nutr Food Res. 2007 Aug;51(8):956-61.

 

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Steinberg D., Parthasarathy S., Care T.E., Khoo J.C., Witztum J.L. Beyond cholesterol: Modifications of lowdensity lipoprotein that increases its atherogenicity. N Engl J Med 1989: 320:915-924

 

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Parthasarathy S. Mechanisms by which dietary antioxidants may prevent cardiovascular diseases. J Medicinal Food 1998; 1:45-51

 

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Street D.A., Comstock G.W., Salkeld R.M., Schuep W., Klag M.J. Serum antioxidants and myocardial infarction. Are levels of carotenoids and alpha-tocopherol risk factors for myocardial infarction? Circulation 1994; 90:1154-1161

 

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Kristenson M., Zieden B., Kucinaskiene Z., Elinder L.S., Bergdahl B., Elwing B., Abaravicius A., Razinkoviene L., Calkauskas H., Olsson A. Antioxidant State and Mortality from Coronary Heart Disease in Lithuanian and Swedish Men: Concomitant Cross Sectional Study of Men Aged 50. BMJ 1997; 314:629-633

 

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G. Riccioni, B. Mancini, E. Di Ilio, T. Bucciarelli, N.D’Orazio - Protective effect of lycopene in cardiovascular disease - European Review for Medical and Pharmacological Sciences 2008; 12: 183-190 [File 135 ERMPS 2008.pdf]

 

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Linseisen J., Hoffmann J., Riedl J., Wolfram G. Effect of a single dose of antioxidant mixture (vitamin E, carotenoids) on the formation of cholesterol oxidation products after ex vivo LDL oxidation in humans. Eur J Med Res 1998; 3:5-12. Pierre srl – Galatina, Italy–Dietary Supplement with Organic Lycopene (Patent n.WO/2008/015490). LICOMPLETE™ was developed by Pierre, working with University of Salento and CNR (National Research Centre)

 

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Heart supplements
Italian health supplement
Organic dietary supplements
Italian cardiovascular health help
Prostate health support manufacturing
Made in Italy sports supplements supplier
Organic dietary supplements manufacturing
Women skin care supplement business supplier
Italian VIP dietaries supplements manufacturing
Organic lycopene the perfect Italian antioxidant
Lycopene dietary supplements for wholesalers
Organic health food dietaries manufacturers
Private label health food distributor supply
VIP Italian organic dietary supplements
Dietary food supplements suppliers
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Welcome to distributors
Made in Italy

CARDIOVASCULAR RISK - PROTECTING YOUR HEALTH
Cardiovascular and coronary heart diseases are the main causes of early death in many developed countries across the world. They are caused by the formation and the development of an atherosclerotic plaque on the internal walls of the arteries. This process is due to the oxidisation of low density lipoproteins (LDL), which produces lipidic deposits (atheromata). LDL is the main carrier of cholesterol into the blood stream. Oxidized LDL (LDLox) are not able to play correctly their role and are removed and destroyed by macrophages. When a LDLox excess occurs, the macrophages become larger, change their aspect and accumulate on the walls of the arteries. The gradual build up of these deposits causes the arteries to narrow and harden, restricting the flow of oxygenated blood to the heart muscle. This can cause angina and, if a coronary artery becomes completely blocked, it can cause permanent damage to the heart muscle or heart attack.

WE ARE LOOKING FOR WORLDWIDE DISTRIBUTORS

 

LYCOMPLETE - LYCOPENE EXTRACTED FROM ORGANIC TOMATOES BY SUPERCRITICAL CO2 FREE OF CHEMICAL SOLVENTS

 

 

ORGANIC LYCOPENE TO THE FOOD SUPPLEMENTS INDUSTRY BY PIERRE GROUP - THE PERFECT ANTIOXIDANT MADE IN ITALY

 

The organic lycopene is an exclusive product worldwide patented by Pierre Group Italy as the perfect antioxidant extracted without solvents or any chemical process directly from ripe red tomatoes... to produce the uniques organic dietary and health supplements products of the health market

LYCOPENE SOURCES Lycopene is a carotenoid, a group of compounds present in many fresh fruits and vegetables. There are more than 750 types of carotenoids in nature; however, only 20 of these have been found in human blood and tissues. The carotenoid most often present in human blood is lycopene ,followed by b -carotene, lutein and zeaxanthin.

 

 RED RIPE TOMATOES THE MAIN SOURCE OF LYCOPENE and their derivatives are the main natural source of lycopene giving approximately 85% of all lycopene in the human body. The amount of lycopene in tomatoes depends the quality of fruit, the environment and cultivation procedures. Usually, the content of lycopene in red-ripe tomatoes is 30-80 mg/kg of fresh product, but it could be more than 150-300 mg/kg in some selected species obtained by traditional hybridization techniques.
PROPERTIES OF ORGANIC LYCOPENE the organic lycopene has a very strong antioxidant power, as antioxidant contrasts the destructive action of free radicals in the human body (which are seriously dangerous for the cells and tissues) protects and prevents against several diseases... SEE FULL INFORMATION

   
  Health prostate organic dietary supplement, after 45 yearsold, men may experience undesired growth of the prostate due to an inflammatory process that can degenerate into cancer. Prostate Health + effectiveness plus, is a special blend of antioxidants, saw palmetto, ginseng and zinc aids in the prevention and reduction of risk factors that cause inflammation of the prostate, produced by Pierre Group in Italy Lycodeep dietary supplement - Aanti aging reducing wrinkles Lycodeep effectively counteracts the aging of the skin by reducing wrinkles and improving the thickness and sagging skin. Lycodeep is the only supplement with "Organic Lycopene" specially formulated for the protection and beautification of the skin. Lycodeep is useful in cellulite treatment. Organic Lycopene coming from Italian tomatoes Lycomplete dietary supplement with organic lycopene is a nutraceutical excellence with Organic Lycopene and other natural active ingredients acting synergistically as antioxidant treatment, specific and effective against oxidative stress. Lycomplete normalizes the value of oxidative stress. Oxidative stress is evident especially in the onset of serious diseases such as cancer, cardiovascular diseases, diabetes and others Lycosport organic dietary supplement to improve performance, Lycosport with organic lycopene, produced in Italy by Pierre Group, is a nutraceutical dietary supplement for the improvement of sports performance. Lycosport is distinguished by its special formulation, consisting of a balanced mixture of natural compounds, antioxidants and amino acids that helps to improve athletic conditions
 

Health Prostate Dietary

Lycodeep skin care supplement

Lycomplete heart supplement

Lycosport athlete supplements

  Licofor is a private label dietary supplement produced to the Barcelona Spain company Bama Geve Vitilicaps nutraceutical product with organic lycopene, produced in private label for Lyconcepts Santo Domingo Naturmio dietary supplement with our organic lycopene produced for Private label to the Italian company Sirton Medicare Spa Milano Licofor dietary supplement produced with our organic lycopene, Private Label product to the company Farmigea in Pisa Italy
 

Lycocor for Italian market

Vitilicaps for Santo Domingo market

Naturmio women for Italian market

Lycofor (eyes optic) for Italian market

 

We offer our full dietary, food and health care supplements manufacturing knowledge plus our engineering capabilities to create, design, produce new supplement products, in Private label, for manufacturers and distributors.

 

Naturmio Health Prostate for Italy

Lycocor for Spain and Portugal market

APPLY FOR PRIVATE LABEL HERE

   

WE PRODUCE ORGANIC LYCOPENE THE MOST IMPORTANT ANTIOXIDANT EXTRACTED FROM RED-RIPE TOMATOS

Pierre Group srl is an Italian manufacturer of organic dietary supplements using made in Italy organic lycopene health care supplementsdietary care supplements manufacturer, organic healthy suppliers, organic medicine pills manufacturing, Italian pharmaceutical technology supply, anticancer medicine vendors, organic lycopene manufacturers. Our mission is to produce the best health and dietary care products for distributors in Europe, USA, Asia Middle East... including the following markets: Italy, Austria, France, USA, Netherlands, England, Scotland, Russia, Spain, Ukraine, Greece, California, Texas, New York, Florida, Illinois, Atlanta in the US, Panama, Australia, Japan, China, India, Chile, Argentina, Brazil, Uruguay, Colombia, Ecuador, Perù, Brasil, Belgium, Saudi Arabia, Oman, Dubai, China, Thailand, Taipei, Finland, Poland, Germany, Norway, England, Romania, Kuwait, Dubai, Oman, UAE, Qatar, Mexico, Uruguay, Paraguay, Costa Rica, Republica Dominicana, Ireland Great Britain, Russia, Scotland, Bolivia, England, Sweden, Canada, the United States, South Korea, Kuwait, China, Japan, Oman, Bahrain, Denmark, Holland, Spain, Colombia, Nicaragua, Puerto Rico, Czech Republic, India, Thailand... supporting the vip wholesale dietary and health supplements distributors worldwide

 

Pierre Group an Italian dietary supplement and beauty care cosmetics manufacturing industry with facilities in Galatina Salento, South of Italy, a certified industry of organic skin care products thanks to our international patent to produce organic lycopene... made in Italy

 

Made in Italy organic dietary supplement and cosmetics manufacturer suppliers, organic producer of health beauty care cosmetics for beauty salon and wholesale distributors in China, Asia, USA, Europe, Africa, Canada, South America and Middle East vendors

 

FOR INFO AND CUSTOMER SERVICES CALL OUR MANUFACTURING FACILITIES: +39.333.6371.644

 

Italian cosmetic manufacturing, industrial manufacturer of beauty care cosmetics for beauty salon and wholesale distributors in China, Asia, USA, Europe, Africa, Canada, South America and Middle East

Nickel tested, each of our dietary supplement product is nickel tested

Our full collection of products are Paraben Free

We use only organic lycopene, coming from our organic Italian tomatoes using a biological extraction co2 system

We do not use chemical solutions or agents to extract the lycopene from tomatoes, we use only the biological extraction system with critical co2 manufacturing process

Non GMO (genetically modified organism) used by Pierre Group for cosmetics and dietary supplement products

Each of our supplements and cosmetics are sodium free to guarantee best sensation and health to your skin

All products of our collection are not tested on animals

About Pierre Group Italy   Dietary supplements   Health food supplement   Made in Italy   Organic lycopene producers   Contact Us

 

Site Map - We invite you to visit our biological health and organic dietary food supplement web pages:

 

Italian organic dietary products  dietary supplements manufacturing  health food supplements manufacturer suppliers  organic supplements wholesale distributors  cardiovascular heart health care supplements  made in italy hearth supplements lycomplete pills  prostate support supplements pharmaceutical USA health care  health prostate organic food supplement  organic sports supplement manufacturing industry  athletes US health food manufacturer for distribution lycosport  skin care food dietary supplements industrial production  women beauty care dietary supplements manufacturing lycodeep  organic lycopene manufacturers vendors for distributors  antioxidants health food supplement US products supply  Italian organic lycopene for private label health supplement  Italian world patented products  Canada certified organic health food medicine technology  Italian organic lycopene properties versus synthetic lycopene market  organic lycopene versus natural lycopene technical specifications  private label production of health dietary supplements  China health food dietary supplements lycocor Spain  organic heart supplements naturmio private label Italy  health food supplement industrial production vitilicaps Santo Domingo  nutraceutical organic lycopene private label for licofor Italy  Italian organic lycopene manufacturing industry  industrial manufacturing process of organic lycopene supplements  supplement products and distributors deals  dietary online store  distribution request

 

Italian beauty skin care comsetics manufacturer and organic health care dietary supplement manufacturing industry using organic lycopene made in Italy

 

PIERRE GROUP SRL "THE ITALIAN ORGANIC DIETARY AND HEALTH LYCOPENE SUPPLEMENTS MANUFACTURING INDUSTRY"

 

Manufacturing facilities - SP 362 Km 17,650 Zona Industriale, 73013 Galatina Lecce, Salento - Italy
Export offices in Italy (English + Spanish + Italian): +39.333.6371.644
Sales offices in England UK: +44.7935.999.251

 

Web: www.supplementsmanufacturing.com                Email: info@supplementsmanufacturing.com

 

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